tecovirimat will increase the degree or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Tecovirimat is really a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse results if coadministered with delicate substrates of such enzymes.
Modafinil appeared to create a focus-relevant suppression of CYP2C9 activity, for that reason suggesting probable for CYP2C9 inhibition; caution if drugs which have a narrow therapeutic index
Angitt pris er maksimal utsalgspris fra apotek. Pakninger som selges uten resept er angitt med stjerne *. Det er fri prisfastsettelse for pakninger som selges uten resept, og maksimal utsalgspris kan derfor ikke angis.
En gruppe legemidler som motvirker depresjon ved å øke konsentrasjonen av signalstoffene noradrenalin og serotonin i hjernen.
voriconazole will raise the amount or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Indicated to further improve wakefulness in Grownups with extreme sleepiness associated with shift function ailment (SWD)
anastrozole will raise the degree or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.
Doses around 400 mg/day, specified as an individual dose, have been properly tolerated, but more info there is no regular proof this dose confers extra benefit beyond that in the 200 mg/day dose
modafinil will improve the level or result of lansoprazole by impacting hepatic enzyme CYP2C19 metabolism. Minimal/Importance Not known. Internet effect on pantoprazole actions unfamiliar on account of opposing outcomes of CYP450 enzymes; monitor
phenytoin will decrease the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
fosphenytoin will reduce the level or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
No satisfactory reports in people have investigated the protection of modafinil use for the duration of pregnancy. Thus, caution is advised, and using modafinil all through pregnancy is mostly only accepted if a qualified healthcare professional has a certain explanation to believe that the potential therapeutic Gains outweigh the probable pitfalls [38].
Although the proof for these numerous “improvement” consequences is generally really weak, unlawful abuse of modafinil carries on to get significantly common amid specialists and college students.
Hence, the steps of any medicine that have to have People enzymes to get processed by the body could be altered or negatively motivated in the course of remedy with modafinil.